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Nemifitide diTFA

Nemifitide diTFA
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide that can cross the blood-brain barrier and acts as a potent antidepressant, similar to melanocyte suppressor factor (MIF).
Catalog No. TP1127Cas No. 204992-09-6
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Purity:99.84%
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Nemifitide diTFA

Purity: 99.84%
Catalog No. TP1127Alias INN 00835 diTFACas No. 204992-09-6

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide that can cross the blood-brain barrier and acts as a potent antidepressant, similar to melanocyte suppressor factor (MIF).
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Product Introduction

Bioactivity
Description
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide that can cross the blood-brain barrier and acts as a potent antidepressant, similar to melanocyte suppressor factor (MIF).
In vitro
Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind to multiple receptors, including 5-HT2A, 5-HT2C, melanocortin MC4, MC5, and bombesin, at micromolar concentrations[2].
In vivo
Administered intraperitoneally at a dose of 0.3 mg/kg daily for 14 days, Nemifitide diTFA (INN 00835 diTFA) significantly increases swimming behavior in the FSL rats after just 5 days of treatment, and this effect has a long-lasting duration[2]. Moreover, across a range of doses (0.0125-15.0 mg/kg), Nemifitide diTFA demonstrates a significant increase in swimming behavior in FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses, but not at intermediate (0.4-2.4 mg/kg) doses[3].
AliasINN 00835 diTFA
Chemical Properties
Molecular Weight922.8
FormulaC37H45F7N10O10
Cas No.204992-09-6
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (216.73 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.0837 mL5.4183 mL10.8366 mL54.1829 mL
5 mM0.2167 mL1.0837 mL2.1673 mL10.8366 mL
10 mM0.1084 mL0.5418 mL1.0837 mL5.4183 mL
20 mM0.0542 mL0.2709 mL0.5418 mL2.7091 mL
50 mM0.0217 mL0.1084 mL0.2167 mL1.0837 mL
100 mM0.0108 mL0.0542 mL0.1084 mL0.5418 mL

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